Honglin Zhai
Professor
Introduction
Honglin Zhai received a B.S. degree in physical chemistry from Lanzhou University in 1986, and then has been working in Lanzhou University. In 2004, he received his Ph.D. degree of analytical chemistry. From 2007 to 2008, he went to the molecular medicine research center in Changgung University inTaiwanto conduct postdoctoral research on anticancer drug design and early cancer diagnosis. His professional skills are modeling and analysis in data mining, pattern recognition, molecular simulation, algorithms design and programming. At present, he is mainly engaged in the simultaneous qualitative and quantitative analysis of multi-component in complex systems, the optimization of experimental conditions, bioinformatics and drug molecular design. Up to now, he has published more than 60 research papers in international SCI academic journals, presided and completed NFSC project and a number of cross-sector projects.
Representative Publications
2. Molecular modeling study on resistance of WT/D473H SMO to antagonists LDE-225 and LEQ-506. Pharmacological Research, 2018, 129: 491-499.
3. An effective approach to quantitative analysis of ternary amino acids in foxtail millet substrate based on Terahertz Spectroscopy. Food Chemistry, 2018, 246: 220-227.
4. Prediction of phosphorylation sites based on Krawtchouk image moments. PROTEINS: Structure, Function, and Bioinformatics, 2017, 85: 2231-2238.
5. Exploring the binding mechanism of Heteroaryldihydropyrimidines and Hepatitis B Virus capsid combined 3D-QSAR and molecular dynamics. Antiviral Research, 2017, 137: 151-164.
6. Krawtchouk image moment method for the simultaneous determination of three drugs in human plasma based on fluorescence three-dimensional spectra. Talanta, 2016, 161: 99-104.
7. An approach to the quantitative analysis of multiple components based on liquid chromatography mass spectrometry in full scan mode. Journal of Separation Science, 2016, 39(15): 3054-3061.
8. The determination of multi-components utilizing 1H NMR three-dimensional spectra combined Tchebichef moments. Chemometrics and Intelligent Laboratory Systems, 2016, 156: 128-136.
9. Study on the active mechanism of β-secretase inhibitors by molecular simulations. European Journal of pharmaceutical sciences, 2015, 76: 138-148.
10. The application of Tchebichef moment method on the quantitative analysis of multiple compounds based on three-dimensional HPLC fingerprint spectra. Analyst, 2015, 140(2): 630-636.
Office:
Room 2039, the First Chemistry Building
TEL:
E-mail:
zhaihl@lzu.edu.cn
Education:
1982－1986，Physical Chemistry, Lanzhou University, B.S.
2001－2004，Analytical Chemistry, Lanzhou University, Ph.D.