Bo Zhou

Introduction

Bo Zhou received a B.S. degree from Gannan Normal University in 1993. He then joined Prof. Zhong-Li Liu’s group at College of Chemistry and Chemical Engineering, Lanzhou University as a graduate student and performed research in the field of free radical chemistry and biology. He got his M.S. and Ph.D. degrees in 1997 and 2000, respectively. He worked as a postdoctoral fellow at Life Science College and State Key Laboratory of Applied Organic Chemistry, Lanzhou University from 2001 to 2004 and became a professor of chemistry at Lanzhou University in December. His current research interests focus on developing natural product-inspired prooxidative anticancer agents by exploiting the redox Achilles heel of cancer cells.


Representative Publications

1.    Dai, F.; Du, Y.-T.; Zheng, Y.-L.; Zhou, B., A promising redox cycle-based strategy for designing a catechol-type diphenylbutadiene as a potent prooxidative anti-melanoma agent. Free Radic. Biol. Med. 2019, 130, 489-498.

2.    Dai, F.; Yan, W.-J.; Fu, X.; Zheng, Y.-L.; Du, Y.-T.; Bao, X.-Z.; Kang, Y.-F.; Jin, X.-L.; Zhou, B., Designing dichlorobinaphthoquinone as a prooxidative anticancer agent based on hydrogen peroxide-responsive in situ production of hydroxyl radicals. Eur. J. Med. Chem. 2018, 159, 317-323.

3.    Ji, Y.; Dai, F.; Zhou, B., Designing salicylaldehyde isonicotinoyl hydrazones as Cu(II) ionophores with tunable chelation and release of copper for hitting redox Achilles heel of cancer cells. Free Radic. Biol. Med. 2018, 129, 215-216.

4.    Bao, X.-Z.; Dai, F.; Li, X.-R.; Zhou, B., Targeting redox vulnerability of cancer cells by prooxidative intervention of a glutathione-activated Cu(II) pro-ionophore: Hitting three birds with one stone. Free Radic. Biol. Med. 2018, 124, 342-352.

5.    Wang, Y.-H.; Dai, F.; Zhou, B., A catechol-type resveratrol analog manifests antiangiogenic action by constructing an efficient catalytic redox cycle with intracellular copper ions and NQO1. Mol. Nutr. Food Res. 2018, 62, 1700969.

6.    Du, Y-T.; Zheng, Y.-L.; Ji, Y.; Dai, F.; Hu, Y.-J.; Zhou, B., Applying an electrophilicity-based strategy to develop a novel Nrf2 activator inspired from dietary [6]-shogaol. J. Agric. Food Chem. 2018, 66, 7983-7994.

7.    Dai, F.; Yan, W.-J.; Du, Y.-T.; Bao, X.-Z.; Li, X.-Z., Zhou, B., Structural basis, chemical driving forces and biological implications of flavones as Cu(II) ionophores. Free Radic. Biol. Med. 2017, 108, 554-563.

8.    Yan, W.-J.; Wang, Q.; Yuan, C.-H.; Wang, F.; Ji, Y.; Dai, F.; Jin, X.-L.; Zhou, B., Designing piperlongumine-directed anticancer agents by an electrophilicity-based prooxidant strategy: A mechanistic investigation. Free Radic. Biol. Med. 2016, 97, 109-123.

9.    Sun, L.-D.; Wang, F.; Dai, F.; Wang, Y.-H.; Lin, D.; Zhou, B., Development and mechanism investigation of a new piperlongumine derivative as a potent anti-inflammatory agent. Biochem. Pharmacol. 2015, 95, 156-169.

10.   Kang,Y.-F.; Yan, W.-J.; Zhou, T. -W.; Dai, F.; Li, X.-Z.; Bao, X.-Z.; Du, Y.-T.; Yuan, C.-H.; Wang, H.-B.; Ren, X.-R.; Liu, Q.; Jin, X.-L.; Zhou, B.; Zhang, J., Tailoring 3,3’-dihydroxyisorenieratene to hydroxystilbene: Finding a resveratrol analogue with increased antiproliferation activity and cell selectivity. Chem. Eur. J. 2014, 20, 8904-8908.

 

 


Office:

Room 4043, the Frist Chemistry Building

TEL:

+86-13639330926

E-mail:

bozhou@lzu.edu.cn

Education:

1989-1993,Gannan Normal University,B.S.

1994-1997,Lanzhou University,M.S.

1997-2000,Lanzhou University, Ph.D.