Introduction

Fang Dai is an associated professor from College of Chemistry and Chemical Engineering, Lanzhou University. Her research interests include developing fluorescent probes for monitoring intracellular redox-active molecules and Nrf2 activators for cancer chemoprevention. She earned a Ph.D. degree from Tianjin Medical University in 2004. After completing her PhD program, she moved to Lanzhou University for postdoctoral studies in chemical biology in Prof. Zhongli Liu’s group at the State Key Laboratory of Applied Organic Chemistry. In 2007, she joined Lanzhou University as an assistant professor.

Representative Publications

1.  Dai, F.; Du, Y.-T.; Zheng, Y.-L.; Zhou, B., A promising redox cycle-based strategy for designing a catechol-type diphenylbutadiene as a potent prooxidative anti-melanoma agent. Free Radic. Biol. Med. 2019, 130, 489-498.

2.  Dai, F.; Yan, W.-J.; Fu, X.; Zheng, Y.-L.; Du, Y.-T.; Bao, X.-Z.; Kang, Y.-F.; Jin, X.-L.; Zhou, B., Designing dichlorobinaphthoquinone as a prooxidative anticancer agent based on hydrogen peroxide-responsive in situ production of hydroxyl radicals. Eur. J. Med. Chem. 2018, 159, 317-323.

3.  Dai, F.; Jin, F.; Long, Y.; Jin, X.-L.; Zhou, B., A 1,8-naphthalimide-based turn-on fluorescent probe for imaging mitochondrial hydrogen peroxide in living cells. Free Radic. Res. 2018, https://doi.org/10.1080/10715762.2018.1446530.

4.  Dai, F.; Wang, Q.; Fan, G.-J.; Du, Y.-T.; Zhou, B., ROS-driven and preferential killing of HepG2 over L-02 cells by a short-term cooperation of Cu(II) and a catechol-type resveratrol analog. Food Chem. 2018, 250, 213-220.

5. Dai, F.; Yuan, C.-H.; Ji, Y.; Du Y.-T.; Bao, X.-Z.; Wu, L.-X; Jin, X.-L.; Zhou, B., Keto-enol-based modification on piperlongumine to generate a potent Cu(II) ionophore that triggers redox imbalance and death of HepG2 cells. Free Radic. Biol. Med. 2018, 120, 124-132.

6.  Du, Y-T.; Zheng, Y.-L.; Ji, Y.; Dai, F.; Hu, Y.-J.; Zhou, B., Applying an electrophilicity-based strategy to develop a novel Nrf2 activator inspired from dietary [6]-shogaol. J. Agric. Food Chem. 2018, 66, 7983-7994.

7.  Dai, F.; Yan, W.-J.; Du, Y.-T.; Bao, X.-Z.; Li, X.-Z., Structural basis, chemical driving forces and biological implications of flavones as Cu(II) ionophores. Free Radic. Biol. Med. 2017, 108, 554-563.

8.  Tu, Z.-S.; Wang, Q.; Sun, D.-D.; Dai, F., Zhou, B., Design, synthesis, and evaluation of curcumin derivatives as Nrf2 activators and cytoprotectors against oxidative death. Eur. J. Med. Chem. 2017, 134, 72-85.

9.  Dai, F.; Liu, G.-Y.; Li. Y.; Yan, W.-J.; Wang, Q.; Yang, J.; Lu, D.-L.; Ding, D.-J.; Lin, D.; Zhou, B., Insights into the importance for designing curcumin-inspired anticancer agents by a prooxidant strategy: The case of diarylpentanoids. Free Radic. Biol. Med. 2015, 85, 127-137.

10.  Lin, D.; Dai, F.; Sun, L.-D.; Zhou, B., Toward an understanding of the role of a catechol moiety in cancer chemoprevention: The case of copper- and o-quinone-dependent Nrf2 activation by a catechol-type resveratrol analog. Mol. Nutr. Food Res. 2015, 59, 2395-2406.

Representative Publications