Baoxin Zhang



Baoxin Zhang studied chemistry and received his B.Sc. from Lanzhou University in 2010, and obtained his Ph.D. in Organic Chemistry under the supervision of professor Jianguo Fang from Lanzhou University in 2015. He then joined the State Key Laboratory of Applied Organic Chemistry in Lanzhou University. His current research interest focuses on the design and synthesis of potential anticancer agents for TrxR and constrction of fluoprescent probe towards bimolecule.

Representative Publications

1.  Zhang, J.; Zhang, B.; Li, X.; Han, X.; Liu, R.; Fang, J. Small molecule inhibitors of mammalian thioredoxin reductase as potential anticancer agents: An update. Medicinal research reviews 2019, 39, 5-39.

2.  Zhang, B.; Liu, Y.; Li, X.; Xu, J.; Fang, J. Small Molecules to Target the Selenoprotein Thioredoxin Reductase. Chemistry – An Asian Journal 2018, 13, 3593-3600.

3. Zhang, B.; Zhang, J.; Peng, S.; Liu, R.; Li, X.; Hou, Y.; Han, X.; Fang, J. Thioredoxin reductase inhibitors: a patent review. Expert opinion on therapeutic patents 2017, 27, 547-556.

4. Zhang, B.; Ge, C.; Yao, J.; Liu, Y.; Xie, H.; Fang, J. Selective Selenol Fluorescent Probes: Design, Synthesis, Structural Determinants, and Biological Applications. Journal of the American Chemical Society 2015, 137, 757-769.

5. Zhang, B.; Duan, D.; Ge, C.; Yao, J.; Liu, Y.; Li, X.; Fang, J. Synthesis of Xanthohumol Analogues and Discovery of Potent Thioredoxin Reductase Inhibitor as Potential Anticancer Agent. Journal of Medicinal Chemistry 2015, 58, 1795-1805.

6. Peng, S.; Zhang, B.; Meng, X.; Yao, J.; Fang, J. Synthesis of Piperlongumine Analogues and Discovery of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Activators as Potential Neuroprotective Agents. Journal of Medicinal Chemistry 2015, 58, 5242-5255.

7. Yao, J.; Zhang, B.; Ge, C.; Peng, S.; Fang, J. Xanthohumol, a Polyphenol Chalcone Present in Hops, Activating Nrf2 Enzymes To Confer Protection against Oxidative Damage in PC12 Cells. Journal of Agricultural and Food Chemistry 2015, 63, 1521-1531.

8. Peng, S.; Zhang, B.; Yao, J.; Duan, D.; Fang, J. Dual protection of hydroxytyrosol, an olive oil polyphenol, against oxidative damage in PC12 cells. Food & Function 2015, 6, 2091-2100.

9. Duan, D.; Zhang, B.; Yao, J.; Liu, Y.; Fang, J. Shikonin targets cytosolic thioredoxin reductase to induce ROS-mediated apoptosis in human promyelocytic leukemia HL-60 cells. Free Radical Biology and Medicine 2014, 70, 182-193.

10. Duan, D.; Zhang, B.; Yao, J.; Liu, Y.; Sun, J.; Ge, C.; Peng, S.; Fang, J. Gambogic acid induces apoptosis in hepatocellular carcinoma SMMC-7721 cells by targeting cytosolic thioredoxin reductase. Free Radical Biology and Medicine 2014, 69, 15-25.


Room 326, the Second Chemistry Building